US Controlled Substances Act
Schedule II drugs list (Schedule 2)
Accepted medical use but a high potential for abuse that may lead to severe psychological or physical dependence.
What it means
Accepted medical use but a high potential for abuse that may lead to severe psychological or physical dependence.
Prescribing and refills
Written or electronic prescription; no refills. Prescribers can issue up to a 90-day supply as several dated prescriptions.
21 Schedule II substances on DoseUses
Amphetamine
Adderall, Adderall XR, Mydayis
Adderall is a mix of four amphetamine salts (about three parts dextroamphetamine to one part levoamphetamine) used to treat ADHD and narcolepsy.
Read profileCarfentanil
Wildnil, Elephant tranquilizer, Gray death (in mixtures)
Carfentanil is a synthetic opioid about 100 times more potent than fentanyl and 10,000 times more potent than morphine.
Read profileCocaine
Goprelto, Numbrino
Cocaine is a stimulant made from the leaves of the coca plant.
Read profileCodeine
Tylenol with Codeine, Tuzistra XR
Codeine is a mild opioid used for pain and, in some products, for cough.
Read profileDexmethylphenidate
Focalin, Focalin XR, Azstarys
Dexmethylphenidate (Focalin) is the more active half of methylphenidate, so it works at about half the dose.
Read profileDextroamphetamine
Dexedrine, Zenzedi, ProCentra
Dextroamphetamine is the more active form (isomer) of amphetamine.
Read profileFentanyl
Duragesic, Actiq, Fentora
Fentanyl is a synthetic opioid about 50 times stronger than heroin and 100 times stronger than morphine.
Read profileHydrocodone
Norco, Vicodin, Lortab
Hydrocodone is a prescription opioid for severe pain, most often combined with acetaminophen in products such as Norco and Vicodin.
Read profileHydromorphone
Dilaudid, Exalgo
Hydromorphone (Dilaudid) is a potent opioid, about five times stronger than morphine by mouth, used for severe pain in hospitals, after surgery, and in cancer care.
Read profileLevorphanol
Levo-Dromoran
Levorphanol is a potent, long-acting prescription opioid for severe pain.
Read profileLisdexamfetamine
Vyvanse
Lisdexamfetamine (Vyvanse) is an inactive prodrug that the body slowly converts into dextroamphetamine.
Read profileMeperidine
Demerol, Pethidine, Demmies
Meperidine (Demerol), called pethidine outside the US, is a synthetic opioid for short-term acute pain.
Read profileMethadone
Methadose, Dolophine
Methadone is a long-acting opioid used to treat opioid use disorder and severe pain.
Read profileMethamphetamine
Desoxyn
Methamphetamine is a powerful stimulant.
Read profileMethylphenidate
Ritalin, Concerta, Metadate CD
Methylphenidate (Ritalin, Concerta) is the most widely used ADHD medicine besides amphetamines.
Read profileMorphine
MS Contin, Kadian, Duramorph
Morphine is the original opioid pain medicine, extracted from the opium poppy, and the standard against which other opioids are measured.
Read profileNabilone
Cesamet
Nabilone (Cesamet) is a prescription synthetic cannabinoid, similar to THC, for nausea and vomiting from chemotherapy that has not responded to standard medicines.
Read profileOxycodone
OxyContin, Roxicodone, Percocet
Oxycodone is a strong prescription opioid used for pain severe enough to need an opioid when other treatments are not enough.
Read profileOxymorphone
Opana, Opana ER, Numorphan
Oxymorphone is a strong prescription opioid for severe pain, roughly twice as potent as oxycodone by mouth.
Read profilePCP
Phencyclidine, Angel dust, Wet
PCP (phencyclidine), also called angel dust, is a dissociative drug developed as an anesthetic in the 1950s and abandoned because of severe agitation and hallucinations in patients.
Read profileTapentadol
Nucynta, Nucynta ER
Tapentadol (Nucynta) is a prescription opioid that also blocks norepinephrine reuptake.
Read profileSource: DEA Diversion Control Division, Controlled Substance Schedules. Some substances are listed in different schedules depending on the product or formulation; see each profile.