Independent drug reference
Drug uses, dosage, side effects, and withdrawal, clearly sourced.
Drug uses, dosage, side effects, interactions, overdose, withdrawal, and the law for 106 prescription and controlled substances, including Xanax, Adderall, and oxycodone. Every fact is clearly sourced from FDA labels, DEA rules, and clinical guidelines and written in plain language.
Popular: Adderall, Xanax, oxycodone, gabapentin, kratom, psilocybin, Narcan, delta-8
Combination checker
Is it safe to mix these?
Choose two substances to see how they interact and why. Based on how each drug works and on FDA warnings.
Explore by drug cluster
All 106 drugsOpioids
Opioids act on mu-opioid receptors in the brain and spinal cord to relieve pain.
Benzodiazepines and sedatives
Sedatives slow the brain.
Stimulants
Stimulants increase dopamine and norepinephrine in the brain, raising alertness, attention, and energy.
Gabapentinoids, dissociatives, and others
This cluster groups medicines with distinctive actions: gabapentinoids for nerve pain and seizures, dissociative anesthetics used in surgery and depression, sodium oxybate for narcolepsy, and synthetic THC.
Cannabis and psychedelics
Cannabis acts on cannabinoid receptors; classic psychedelics such as psilocybin, LSD, DMT, and mescaline act on serotonin 5-HT2A receptors; MDMA releases serotonin and other chemicals.
Anabolic steroids
Anabolic-androgenic steroids are synthetic or natural versions of testosterone.
Emerging and unscheduled substances
New and re-emerging substances are reshaping the drug supply.
Tools and guides
Interactive tools built on the same sourced data as every profile.
Drugs A to Z
106 profiles of prescription and controlled substances, filterable by class and schedule.
OpenCombination checker
Pick any two substances and see how dangerous the mix is, and why.
OpenCompare drugs
Put up to three drugs side by side: onset, duration, half-life, schedule, and risks.
OpenOverdose help
Step-by-step guide to recognizing and responding to an overdose, including naloxone.
OpenWithdrawal
What to expect when stopping, drug by drug, and why tapering matters.
OpenLegal status
The five US drug schedules, what each allows, and 2026 changes.
OpenHow we work
Built to be trusted, not to sell
DoseUses has no pharmacy, no affiliate links, and nothing to sell. Our job is to explain what the evidence and the law say, clearly enough to act on safely.
Read our editorial policy- Primary sources onlyFDA prescribing information, DEA rules and the Federal Register, NIDA, CDC, and clinical guidelines. Every claim is cited.
- Medical reviewProfiles are marked as drafts and kept out of search engines until a licensed clinician has reviewed them.
- Safety first, never salesWe explain the legal routes to treatment, how to spot illegal sellers, and how to respond to an overdose.
Latest updates
All posts- Can controlled medicines be prescribed by telehealth in 2026?Federal rules let DEA-registered clinicians prescribe controlled medicines after a telemedicine visit through December 31, 2026. Here is what the rule covers and what could change.
- How much naloxone is safe? Dosing, side effects, and overdose signsNaloxone is an emergency medicine that reverses opioid overdose by knocking opioids off their receptors. Narcan and RiVive nasal sprays have been sold...
- Is 7-OH safe or legal? Effects, risks, and the law in 20267-OH (7-hydroxymitragynine) is a potent opioid compound found in trace amounts in kratom and sold in concentrated tablets, gummies, and shots in gas...
- Is delta-8 THC safe or legal? Effects, risks, and the law in 2026Delta-8 THC is an intoxicating cannabinoid usually made by chemically converting hemp-derived CBD. It has been sold widely in gas stations, vape shops...
- Is medetomidine safe or legal? Effects, risks, and the law in 2026Medetomidine is a powerful veterinary sedative that, since late 2024, has replaced xylazine as a common adulterant in illicit fentanyl in Philadelphia...
One fake pill can kill
Pills sold outside a pharmacy are often counterfeit and can contain fentanyl or nitazenes. They cannot be told apart by appearance. Carry naloxone and know the signs of an overdose.