US Controlled Substances Act
Schedule I drugs list (Schedule 1)
No currently accepted medical use in the US and a high potential for abuse. These drugs cannot be prescribed; they can be used only in DEA-registered research.
What it means
No currently accepted medical use in the US and a high potential for abuse. These drugs cannot be prescribed; they can be used only in DEA-registered research.
Prescribing and refills
Cannot be prescribed. Research only, under DEA registration.
18 Schedule I substances on DoseUses
2C-B
4-Bromo-2,5-dimethoxyphenethylamine, Nexus, Bees
2C-B is a synthetic psychedelic related to mescaline, first made in 1974.
Read profile5-MeO-DMT
5-methoxy-N,N-dimethyltryptamine, Bufo, Toad
5-MeO-DMT is a very potent, short-acting psychedelic found in the venom of the Sonoran Desert toad and some plants, and also made synthetically.
Read profileAyahuasca
Hoasca, Yagé, Daime
Ayahuasca is a psychedelic brew from the Amazon, usually made from Banisteriopsis caapi vine and Psychotria viridis leaves.
Read profileBromazolam
Designer Xanax, Fake bars, Benzo dope (with fentanyl)
Bromazolam is a designer benzodiazepine never approved anywhere as a medicine.
Read profileCannabis
Marijuana, Weed, Pot
Cannabis is a plant whose main psychoactive compound is THC.
Read profileDMT
Dimethyltryptamine, Dimitri, Ayahuasca
DMT (dimethyltryptamine) is a powerful, short-acting psychedelic found in many plants.
Read profileEtizolam
Etilaam, Depas, Etizest
Etizolam is a benzodiazepine-like drug prescribed for anxiety in Japan, Italy, and India but never approved in the US.
Read profileGHB
Gamma-hydroxybutyrate, GBL, 1,4-butanediol
GHB (gamma-hydroxybutyrate) is a central nervous system depressant sold illegally as a clear liquid or powder.
Read profileHeroin
Diacetylmorphine, Diamorphine, Dope
Heroin is an illegal opioid made from morphine.
Read profileIbogaine
Iboga, Tabernanthe iboga
Ibogaine is a psychedelic from the root bark of the African iboga shrub.
Read profileKhat
Catha edulis, Qat, Miraa
Khat is a shrub whose fresh leaves are chewed for a stimulant effect in East Africa and the Arabian Peninsula.
Read profileLSD
Acid, Lucy, Tabs
LSD (lysergic acid diethylamide) is a very potent psychedelic, active in millionths of a gram, with effects lasting 8 to 12 hours.
Read profileMDMA
Ecstasy, Molly, E
MDMA, sold as ecstasy or molly, is a stimulant and empathy-enhancing drug that releases large amounts of serotonin.
Read profileMescaline
Peyote, San Pedro, Buttons
Mescaline is a psychedelic found in the peyote cactus and some other cacti, such as San Pedro.
Read profileNitazenes
Benzimidazole-opioids, Isotonitazene, Protonitazene
Nitazenes are a group of synthetic opioids, first made in the 1950s but never approved as medicines, that have appeared in the illicit drug supply since 2019.
Read profilePsilocybin
Magic mushrooms, Shrooms, Mushies
Psilocybin is the psychedelic compound in "magic mushrooms".
Read profileSynthetic cannabinoids
K2, Spice, Fake weed
Synthetic cannabinoids, sold as K2 or Spice, are lab-made chemicals sprayed onto plant material or sold as vape liquids.
Read profileSynthetic cathinones
Bath salts, Flakka (alpha-PVP), Mephedrone
Synthetic cathinones are lab-made stimulants related to khat, sold as 'bath salts', 'flakka', or disguised as molly or other drugs.
Read profileSource: DEA Diversion Control Division, Controlled Substance Schedules. Some substances are listed in different schedules depending on the product or formulation; see each profile.