US Controlled Substances Act
Schedule V drugs list (Schedule 5)
Accepted medical use, with a lower potential for abuse than Schedule IV. Includes some low-dose codeine cough preparations.
What it means
Accepted medical use, with a lower potential for abuse than Schedule IV. Includes some low-dose codeine cough preparations.
Prescribing and refills
Prescription usually required; refills as authorized. Some states allow limited pharmacist sales of certain products.
6 Schedule V substances on DoseUses
Brivaracetam
Briviact
Brivaracetam (Briviact) is a prescription antiseizure medicine for partial-onset seizures in people 1 month and older.
Read profileCenobamate
Xcopri
Cenobamate (Xcopri) is a prescription antiseizure medicine for partial-onset seizures in adults, approved in 2019.
Read profileDiphenoxylate and atropine
Lomotil, Lonox
Lomotil combines diphenoxylate, an opioid-related drug that slows the gut, with a small dose of atropine added to discourage misuse.
Read profileLacosamide
Vimpat, Motpoly XR
Lacosamide (Vimpat) is a prescription antiseizure medicine for partial-onset seizures and, as add-on therapy, generalized tonic-clonic seizures.
Read profilePregabalin
Lyrica, Lyrica CR
Pregabalin (Lyrica) is a nerve pain and antiseizure medicine used for diabetic nerve pain, shingles pain, fibromyalgia, spinal cord injury pain, and partial seizures.
Read profilePromethazine with codeine
Phenergan with Codeine, Lean, Purple drank
Promethazine with codeine is a prescription cough syrup that combines codeine, an opioid, with promethazine, a sedating antihistamine.
Read profileSource: DEA Diversion Control Division, Controlled Substance Schedules. Some substances are listed in different schedules depending on the product or formulation; see each profile.