DoseUses

Drug schedules explained: US legal status

The Controlled Substances Act sorts drugs into five schedules. The schedule decides whether a substance can be prescribed, how it can be refilled, and the penalties for possessing it without a prescription.

2026 changes

  • Medical marijuana to Schedule III (April 2026); adult-use cannabis remains Schedule I. Details
  • Hemp THC products restricted from November 12, 2026. Details
  • Tianeptine proposed for Schedule I (July 2026). Details
  • 7-OH kratom compounds scheduled (August 2026). Details
  • Xylazine bill passed the House (September 2026). Details
  • Telehealth prescribing flexibilities run through December 31, 2026. Details

The US drug schedules

  1. I
    Schedule INo currently accepted medical use in the US and a high potential for abuse. These drugs cannot be prescribed; they can be used only in DEA-registered research.18 on DoseUses
  2. II
    Schedule IIAccepted medical use but a high potential for abuse that may lead to severe psychological or physical dependence.21 on DoseUses
  3. III
    Schedule IIIAccepted medical use, with moderate to low potential for physical and psychological dependence.14 on DoseUses
  4. IV
    Schedule IVAccepted medical use, with a low potential for abuse relative to Schedule III.25 on DoseUses
  5. V
    Schedule VAccepted medical use, with a lower potential for abuse than Schedule IV. Includes some low-dose codeine cough preparations.6 on DoseUses
  6. NC
    Not federally controlledNot listed in any federal schedule. Some are prescription medicines, some are veterinary drugs, and some are sold without regulation. States may control them, and federal scheduling may be pending.22 on DoseUses

Source: DEA Diversion Control Division.

All 106 substances

SubstanceUS statusTypeAccess
2C-BSchedule INo US medical routeUS law
5-MeO-DMTSchedule INo US medical routeUS law
7-OH (7-hydroxymitragynine)Not federally controlledUnapproved or unregulatedUS law
AlprazolamSchedule IVPrescription medicineHow to get it legally
Amanita muscariaNot federally controlledUnapproved or unregulatedUS law
AmphetamineSchedule IIPrescription medicineHow to get it legally
ArmodafinilSchedule IVPrescription medicineHow to get it legally
AyahuascaSchedule INo US medical routeUS law
BrivaracetamSchedule VPrescription medicineHow to get it legally
BromazolamSchedule INo US medical routeUS law
BuprenorphineSchedule IIIPrescription medicineHow to get it legally
ButalbitalSchedule IIIPrescription medicineHow to get it legally
ButorphanolSchedule IVPrescription medicineHow to get it legally
CaffeineNot federally controlledOver-the-counter medicineHow to buy it safely
CannabisSchedule INo US medical routeUS law
CarfentanilSchedule IINo US medical routeUS law
CarisoprodolSchedule IVPrescription medicineHow to get it legally
CBDNot federally controlledUnapproved or unregulatedUS law
CenobamateSchedule VPrescription medicineHow to get it legally
ChlordiazepoxideSchedule IVPrescription medicineHow to get it legally
ClonazepamSchedule IVPrescription medicineHow to get it legally
ClorazepateSchedule IVPrescription medicineHow to get it legally
CocaineSchedule IINo US medical routeUS law
CodeineSchedule IIPrescription medicineHow to get it legally
CyclobenzaprineNot federally controlledPrescription medicineHow to get it legally
DaridorexantSchedule IVPrescription medicineHow to get it legally
Delta-8 THCNot federally controlledUnapproved or unregulatedUS law
DexmethylphenidateSchedule IIPrescription medicineHow to get it legally
DextroamphetamineSchedule IIPrescription medicineHow to get it legally
DextromethorphanNot federally controlledOver-the-counter medicineHow to buy it safely
DiazepamSchedule IVPrescription medicineHow to get it legally
DiethylpropionSchedule IVPrescription medicineHow to get it legally
DiphenhydramineNot federally controlledOver-the-counter medicineHow to buy it safely
Diphenoxylate and atropineSchedule VPrescription medicineHow to get it legally
DMTSchedule INo US medical routeUS law
DronabinolSchedule IIIPrescription medicineHow to get it legally
EsketamineSchedule IIIPrescription medicineHow to get it legally
EszopicloneSchedule IVPrescription medicineHow to get it legally
EtizolamSchedule INo US medical routeUS law
FentanylSchedule IIPrescription medicineHow to get it legally
GabapentinNot federally controlledPrescription medicineHow to get it legally
GHBSchedule INo US medical routeUS law
HeroinSchedule INo US medical routeUS law
HHCNot federally controlledUnapproved or unregulatedUS law
HydrocodoneSchedule IIPrescription medicineHow to get it legally
HydromorphoneSchedule IIPrescription medicineHow to get it legally
IbogaineSchedule INo US medical routeUS law
KetamineSchedule IIIPrescription medicineHow to get it legally
KhatSchedule INo US medical routeUS law
KratomNot federally controlledUnapproved or unregulatedUS law
LacosamideSchedule VPrescription medicineHow to get it legally
LevorphanolSchedule IIPrescription medicineHow to get it legally
LisdexamfetamineSchedule IIPrescription medicineHow to get it legally
LoperamideNot federally controlledOver-the-counter medicineHow to buy it safely
LorazepamSchedule IVPrescription medicineHow to get it legally
LSDSchedule INo US medical routeUS law
MDMASchedule INo US medical routeUS law
MedetomidineNot federally controlledUnapproved or unregulatedUS law
MeperidineSchedule IIPrescription medicineHow to get it legally
MescalineSchedule INo US medical routeUS law
MethadoneSchedule IIPrescription medicineHow to get it legally
MethamphetamineSchedule IINo US medical routeUS law
MethandrostenoloneSchedule IIINo US medical routeUS law
MethylphenidateSchedule IIPrescription medicineHow to get it legally
MidazolamSchedule IVPrescription medicineHow to get it legally
ModafinilSchedule IVPrescription medicineHow to get it legally
MorphineSchedule IIPrescription medicineHow to get it legally
NabiloneSchedule IIPrescription medicineHow to get it legally
NaloxoneNot federally controlledOver-the-counter medicineHow to buy it safely
NaltrexoneNot federally controlledPrescription medicineHow to get it legally
NandroloneSchedule IIIPrescription medicineHow to get it legally
NitazenesSchedule INo US medical routeUS law
Nitrous oxideNot federally controlledUnapproved or unregulatedUS law
OxandroloneSchedule IIINo US medical routeUS law
OxazepamSchedule IVPrescription medicineHow to get it legally
OxycodoneSchedule IIPrescription medicineHow to get it legally
OxymetholoneSchedule IIIPrescription medicineHow to get it legally
OxymorphoneSchedule IIPrescription medicineHow to get it legally
PCPSchedule IINo US medical routeUS law
PhendimetrazineSchedule IIIPrescription medicineHow to get it legally
PhenibutNot federally controlledUnapproved or unregulatedUS law
PhenobarbitalSchedule IVPrescription medicineHow to get it legally
PhentermineSchedule IVPrescription medicineHow to get it legally
PregabalinSchedule VPrescription medicineHow to get it legally
Promethazine with codeineSchedule VPrescription medicineHow to get it legally
PseudoephedrineNot federally controlledOver-the-counter medicineHow to buy it safely
PsilocybinSchedule INo US medical routeUS law
Salvia divinorumNot federally controlledUnapproved or unregulatedUS law
SARMsNot federally controlledUnapproved or unregulatedUS law
Sodium oxybateSchedule IIIPrescription medicineHow to get it legally
SolriamfetolSchedule IVPrescription medicineHow to get it legally
StanozololSchedule IIINo US medical routeUS law
SuvorexantSchedule IVPrescription medicineHow to get it legally
Synthetic cannabinoidsSchedule INo US medical routeUS law
Synthetic cathinonesSchedule INo US medical routeUS law
TapentadolSchedule IIPrescription medicineHow to get it legally
TemazepamSchedule IVPrescription medicineHow to get it legally
TestosteroneSchedule IIIPrescription medicineHow to get it legally
TianeptineNot federally controlledUnapproved or unregulatedUS law
TramadolSchedule IVPrescription medicineHow to get it legally
TrenboloneSchedule IIINo US medical routeUS law
TriazolamSchedule IVPrescription medicineHow to get it legally
XylazineNot federally controlledUnapproved or unregulatedUS law
ZaleplonSchedule IVPrescription medicineHow to get it legally
ZolpidemSchedule IVPrescription medicineHow to get it legally
ZuranoloneSchedule IVPrescription medicineHow to get it legally

The legal route to a prescription medicine

  1. See a licensed clinicianIn person or, through December 31, 2026, by telemedicine under federal flexibilities.
  2. Get a prescriptionControlled medicines need a clinician registered with the DEA.
  3. Fill it at a licensed pharmacyIn person or by mail from a pharmacy licensed in your state.

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In an emergency in the US, call 911. Poison Help: 1-800-222-1222.