Drug schedules explained: US legal status
The Controlled Substances Act sorts drugs into five schedules. The schedule decides whether a substance can be prescribed, how it can be refilled, and the penalties for possessing it without a prescription.
2026 changes
- Medical marijuana to Schedule III (April 2026); adult-use cannabis remains Schedule I. Details
- Hemp THC products restricted from November 12, 2026. Details
- Tianeptine proposed for Schedule I (July 2026). Details
- 7-OH kratom compounds scheduled (August 2026). Details
- Xylazine bill passed the House (September 2026). Details
- Telehealth prescribing flexibilities run through December 31, 2026. Details
The US drug schedules
- ISchedule INo currently accepted medical use in the US and a high potential for abuse. These drugs cannot be prescribed; they can be used only in DEA-registered research.18 on DoseUses
- IISchedule IIAccepted medical use but a high potential for abuse that may lead to severe psychological or physical dependence.21 on DoseUses
- IIISchedule IIIAccepted medical use, with moderate to low potential for physical and psychological dependence.14 on DoseUses
- IVSchedule IVAccepted medical use, with a low potential for abuse relative to Schedule III.25 on DoseUses
- VSchedule VAccepted medical use, with a lower potential for abuse than Schedule IV. Includes some low-dose codeine cough preparations.6 on DoseUses
- NCNot federally controlledNot listed in any federal schedule. Some are prescription medicines, some are veterinary drugs, and some are sold without regulation. States may control them, and federal scheduling may be pending.22 on DoseUses
Source: DEA Diversion Control Division.
All 106 substances
| Substance | US status | Type | Access |
|---|---|---|---|
| 2C-B | Schedule I | No US medical route | US law |
| 5-MeO-DMT | Schedule I | No US medical route | US law |
| 7-OH (7-hydroxymitragynine) | Not federally controlled | Unapproved or unregulated | US law |
| Alprazolam | Schedule IV | Prescription medicine | How to get it legally |
| Amanita muscaria | Not federally controlled | Unapproved or unregulated | US law |
| Amphetamine | Schedule II | Prescription medicine | How to get it legally |
| Armodafinil | Schedule IV | Prescription medicine | How to get it legally |
| Ayahuasca | Schedule I | No US medical route | US law |
| Brivaracetam | Schedule V | Prescription medicine | How to get it legally |
| Bromazolam | Schedule I | No US medical route | US law |
| Buprenorphine | Schedule III | Prescription medicine | How to get it legally |
| Butalbital | Schedule III | Prescription medicine | How to get it legally |
| Butorphanol | Schedule IV | Prescription medicine | How to get it legally |
| Caffeine | Not federally controlled | Over-the-counter medicine | How to buy it safely |
| Cannabis | Schedule I | No US medical route | US law |
| Carfentanil | Schedule II | No US medical route | US law |
| Carisoprodol | Schedule IV | Prescription medicine | How to get it legally |
| CBD | Not federally controlled | Unapproved or unregulated | US law |
| Cenobamate | Schedule V | Prescription medicine | How to get it legally |
| Chlordiazepoxide | Schedule IV | Prescription medicine | How to get it legally |
| Clonazepam | Schedule IV | Prescription medicine | How to get it legally |
| Clorazepate | Schedule IV | Prescription medicine | How to get it legally |
| Cocaine | Schedule II | No US medical route | US law |
| Codeine | Schedule II | Prescription medicine | How to get it legally |
| Cyclobenzaprine | Not federally controlled | Prescription medicine | How to get it legally |
| Daridorexant | Schedule IV | Prescription medicine | How to get it legally |
| Delta-8 THC | Not federally controlled | Unapproved or unregulated | US law |
| Dexmethylphenidate | Schedule II | Prescription medicine | How to get it legally |
| Dextroamphetamine | Schedule II | Prescription medicine | How to get it legally |
| Dextromethorphan | Not federally controlled | Over-the-counter medicine | How to buy it safely |
| Diazepam | Schedule IV | Prescription medicine | How to get it legally |
| Diethylpropion | Schedule IV | Prescription medicine | How to get it legally |
| Diphenhydramine | Not federally controlled | Over-the-counter medicine | How to buy it safely |
| Diphenoxylate and atropine | Schedule V | Prescription medicine | How to get it legally |
| DMT | Schedule I | No US medical route | US law |
| Dronabinol | Schedule III | Prescription medicine | How to get it legally |
| Esketamine | Schedule III | Prescription medicine | How to get it legally |
| Eszopiclone | Schedule IV | Prescription medicine | How to get it legally |
| Etizolam | Schedule I | No US medical route | US law |
| Fentanyl | Schedule II | Prescription medicine | How to get it legally |
| Gabapentin | Not federally controlled | Prescription medicine | How to get it legally |
| GHB | Schedule I | No US medical route | US law |
| Heroin | Schedule I | No US medical route | US law |
| HHC | Not federally controlled | Unapproved or unregulated | US law |
| Hydrocodone | Schedule II | Prescription medicine | How to get it legally |
| Hydromorphone | Schedule II | Prescription medicine | How to get it legally |
| Ibogaine | Schedule I | No US medical route | US law |
| Ketamine | Schedule III | Prescription medicine | How to get it legally |
| Khat | Schedule I | No US medical route | US law |
| Kratom | Not federally controlled | Unapproved or unregulated | US law |
| Lacosamide | Schedule V | Prescription medicine | How to get it legally |
| Levorphanol | Schedule II | Prescription medicine | How to get it legally |
| Lisdexamfetamine | Schedule II | Prescription medicine | How to get it legally |
| Loperamide | Not federally controlled | Over-the-counter medicine | How to buy it safely |
| Lorazepam | Schedule IV | Prescription medicine | How to get it legally |
| LSD | Schedule I | No US medical route | US law |
| MDMA | Schedule I | No US medical route | US law |
| Medetomidine | Not federally controlled | Unapproved or unregulated | US law |
| Meperidine | Schedule II | Prescription medicine | How to get it legally |
| Mescaline | Schedule I | No US medical route | US law |
| Methadone | Schedule II | Prescription medicine | How to get it legally |
| Methamphetamine | Schedule II | No US medical route | US law |
| Methandrostenolone | Schedule III | No US medical route | US law |
| Methylphenidate | Schedule II | Prescription medicine | How to get it legally |
| Midazolam | Schedule IV | Prescription medicine | How to get it legally |
| Modafinil | Schedule IV | Prescription medicine | How to get it legally |
| Morphine | Schedule II | Prescription medicine | How to get it legally |
| Nabilone | Schedule II | Prescription medicine | How to get it legally |
| Naloxone | Not federally controlled | Over-the-counter medicine | How to buy it safely |
| Naltrexone | Not federally controlled | Prescription medicine | How to get it legally |
| Nandrolone | Schedule III | Prescription medicine | How to get it legally |
| Nitazenes | Schedule I | No US medical route | US law |
| Nitrous oxide | Not federally controlled | Unapproved or unregulated | US law |
| Oxandrolone | Schedule III | No US medical route | US law |
| Oxazepam | Schedule IV | Prescription medicine | How to get it legally |
| Oxycodone | Schedule II | Prescription medicine | How to get it legally |
| Oxymetholone | Schedule III | Prescription medicine | How to get it legally |
| Oxymorphone | Schedule II | Prescription medicine | How to get it legally |
| PCP | Schedule II | No US medical route | US law |
| Phendimetrazine | Schedule III | Prescription medicine | How to get it legally |
| Phenibut | Not federally controlled | Unapproved or unregulated | US law |
| Phenobarbital | Schedule IV | Prescription medicine | How to get it legally |
| Phentermine | Schedule IV | Prescription medicine | How to get it legally |
| Pregabalin | Schedule V | Prescription medicine | How to get it legally |
| Promethazine with codeine | Schedule V | Prescription medicine | How to get it legally |
| Pseudoephedrine | Not federally controlled | Over-the-counter medicine | How to buy it safely |
| Psilocybin | Schedule I | No US medical route | US law |
| Salvia divinorum | Not federally controlled | Unapproved or unregulated | US law |
| SARMs | Not federally controlled | Unapproved or unregulated | US law |
| Sodium oxybate | Schedule III | Prescription medicine | How to get it legally |
| Solriamfetol | Schedule IV | Prescription medicine | How to get it legally |
| Stanozolol | Schedule III | No US medical route | US law |
| Suvorexant | Schedule IV | Prescription medicine | How to get it legally |
| Synthetic cannabinoids | Schedule I | No US medical route | US law |
| Synthetic cathinones | Schedule I | No US medical route | US law |
| Tapentadol | Schedule II | Prescription medicine | How to get it legally |
| Temazepam | Schedule IV | Prescription medicine | How to get it legally |
| Testosterone | Schedule III | Prescription medicine | How to get it legally |
| Tianeptine | Not federally controlled | Unapproved or unregulated | US law |
| Tramadol | Schedule IV | Prescription medicine | How to get it legally |
| Trenbolone | Schedule III | No US medical route | US law |
| Triazolam | Schedule IV | Prescription medicine | How to get it legally |
| Xylazine | Not federally controlled | Unapproved or unregulated | US law |
| Zaleplon | Schedule IV | Prescription medicine | How to get it legally |
| Zolpidem | Schedule IV | Prescription medicine | How to get it legally |
| Zuranolone | Schedule IV | Prescription medicine | How to get it legally |
The legal route to a prescription medicine
- See a licensed clinicianIn person or, through December 31, 2026, by telemedicine under federal flexibilities.
- Get a prescriptionControlled medicines need a clinician registered with the DEA.
- Fill it at a licensed pharmacyIn person or by mail from a pharmacy licensed in your state.