Home Interactions Drug interaction checker Pick any two substances to see how risky the combination is and why. The checker uses how each drug acts in the body and FDA warnings, so it flags the most dangerous mixes first.
First substance Choose… Alcohol SSRI or SNRI antidepressant MAOI antidepressant Lithium Buprenorphine Butorphanol Carfentanil Codeine Diphenoxylate and atropine Fentanyl Heroin Hydrocodone Hydromorphone Levorphanol Loperamide Meperidine Methadone Morphine Naloxone Naltrexone Oxycodone Oxymorphone Promethazine with codeine Tapentadol Tramadol Alprazolam Butalbital Carisoprodol Chlordiazepoxide Clonazepam Clorazepate Cyclobenzaprine Daridorexant Diazepam Diphenhydramine Eszopiclone GHB Lorazepam Midazolam Oxazepam Phenobarbital Suvorexant Temazepam Triazolam Zaleplon Zolpidem Amphetamine Armodafinil Caffeine Cocaine Dexmethylphenidate Dextroamphetamine Diethylpropion Khat Lisdexamfetamine Methamphetamine Methylphenidate Modafinil Phendimetrazine Phentermine Pseudoephedrine Solriamfetol Synthetic cathinones Brivaracetam Cenobamate Dextromethorphan Dronabinol Esketamine Gabapentin Ketamine Lacosamide Nitrous oxide Pregabalin Sodium oxybate Zuranolone 2C-B 5-MeO-DMT Amanita muscaria Ayahuasca Cannabis CBD Delta-8 THC DMT Ibogaine LSD MDMA Mescaline Nabilone Psilocybin Salvia divinorum Synthetic cannabinoids Methandrostenolone Nandrolone Oxandrolone Oxymetholone SARMs Stanozolol Testosterone Trenbolone 7-OH (7-hydroxymitragynine) Bromazolam Etizolam HHC Kratom Medetomidine Nitazenes PCP Phenibut Tianeptine Xylazine Second substance Choose… Alcohol SSRI or SNRI antidepressant MAOI antidepressant Lithium Buprenorphine Butorphanol Carfentanil Codeine Diphenoxylate and atropine Fentanyl Heroin Hydrocodone Hydromorphone Levorphanol Loperamide Meperidine Methadone Morphine Naloxone Naltrexone Oxycodone Oxymorphone Promethazine with codeine Tapentadol Tramadol Alprazolam Butalbital Carisoprodol Chlordiazepoxide Clonazepam Clorazepate Cyclobenzaprine Daridorexant Diazepam Diphenhydramine Eszopiclone GHB Lorazepam Midazolam Oxazepam Phenobarbital Suvorexant Temazepam Triazolam Zaleplon Zolpidem Amphetamine Armodafinil Caffeine Cocaine Dexmethylphenidate Dextroamphetamine Diethylpropion Khat Lisdexamfetamine Methamphetamine Methylphenidate Modafinil Phendimetrazine Phentermine Pseudoephedrine Solriamfetol Synthetic cathinones Brivaracetam Cenobamate Dextromethorphan Dronabinol Esketamine Gabapentin Ketamine Lacosamide Nitrous oxide Pregabalin Sodium oxybate Zuranolone 2C-B 5-MeO-DMT Amanita muscaria Ayahuasca Cannabis CBD Delta-8 THC DMT Ibogaine LSD MDMA Mescaline Nabilone Psilocybin Salvia divinorum Synthetic cannabinoids Methandrostenolone Nandrolone Oxandrolone Oxymetholone SARMs Stanozolol Testosterone Trenbolone 7-OH (7-hydroxymitragynine) Bromazolam Etizolam HHC Kratom Medetomidine Nitazenes PCP Phenibut Tianeptine Xylazine
Choose two substances to see the result.
Dangerous High risk Caution Low known risk
Not a complete check. This tool groups substances by how they act. It cannot account for doses, health conditions, or every enzyme interaction, and street drugs often contain other substances. A pharmacist can check your full medication list.
Interaction tables for each substance
Every profile has a detailed table of specific interactions from its FDA label or public health sources.